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C2-Symmetric Sc(III)-Complexes as Chiral Lewis Acids. Catalytic Enantioselective Aldol Additions to Glyoxylate Esters

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journal contribution
posted on 07.09.2002, 00:00 by David A. Evans, Craig E. Masse, Jimmy Wu
Cationic Lewis acid complexes [Sc(pyridyl-bis(oxazolinyl)](Cl2)SbF6 1a and 1b catalyze aldol reactions with ethyl glyoxylate with enantioselectivities ranging from 90 to 99% ee and syn reaction diastereoselections ranging from 90:10 to 95:5.