American Chemical Society
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α‑Methylation of 2‑Arylacetonitrile by a Trimethylamine-Borane/CO2 System

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journal contribution
posted on 2019-07-23, 12:37 authored by Xiaowei Zhang, Sheng Wang, Chanjuan Xi
A highly selective monomethylation of 2-arylacetonitrile using CO2 is described. The utilization of trimethylamine-borane facilitates the six-electron reduction of CO2. This reaction is the first selective six-electron reductive functionalization of CO2 faciliated by C­(sp3)–H bonds. A variety of 2-arylpropionitrile was obtained in good yields. The reaction could also be applied at the gram scale.