American Chemical Society
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α‑Aryl-Substituted Allenamides in an Imino-Nazarov Cyclization Cascade Catalyzed by Au(I)

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journal contribution
posted on 2012-11-16, 00:00 authored by Zhi-Xiong Ma, Shuzhong He, Wangze Song, Richard P. Hsung
An imino-Nazarov cyclization using α-aryl-substituted allenamides is described. This gold(I)-catalyzed cascade is efficient and regioselective in constructing a diverse array of synthetically useful aromatic-ring fused cyclopentenamides. The success in this transformation represents a solution to the challenge in establishing an imino-Nazarov cyclization process.