posted on 2012-11-16, 00:00authored byZhi-Xiong Ma, Shuzhong He, Wangze Song, Richard P. Hsung
An imino-Nazarov cyclization using α-aryl-substituted allenamides is described. This gold(I)-catalyzed cascade is efficient and regioselective in constructing a diverse array of synthetically useful aromatic-ring fused cyclopentenamides. The success in this transformation represents a solution to the challenge in establishing an imino-Nazarov cyclization process.