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[60]Fullerene is a Powerful Antioxidant in Vivo with No Acute or Subacute Toxicity

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journal contribution
posted on 2005-12-14, 00:00 authored by Najla Gharbi, Monique Pressac, Michelle Hadchouel, Henri Szwarc, Stephen R. Wilson, Fathi Moussa
In the present work, we report the effects of C60-pretreatments on acute carbon tetrachloride intoxication in rats, a classical model for studying free-radical-mediated liver injury. Our results show that aqueous C60 suspensions prepared without using any polar organic solvent not only have no acute or subacute toxicity in rodents but they also protect their livers in a dose-dependent manner against free-radical damage. To be sure, according to histopathological examinations and biological tests, pristine C60 can be considered as a powerful liver-protective agent.