[60]Fullerene is a Powerful Antioxidant in Vivo with No Acute or Subacute Toxicity

In the present work, we report the effects of C₆₀-pretreatments on acute carbon tetrachloride intoxication in rats, a classical model for studying free-radical-mediated liver injury. Our results show that aqueous C₆₀ suspensions prepared without using any polar organic solvent not only have no acute or subacute toxicity in rodents but they also protect their livers in a dose-dependent manner against free-radical damage. To be sure, according to histopathological examinations and biological tests, pristine C₆₀ can be considered as a powerful liver-protective agent.