ol5b00445_si_001.pdf (1.22 MB)
[4 + 2] Cycloaddition of in Situ Generated 1,2-Diaza-1,3-dienes with Simple Olefins: Facile Approaches to Tetrahydropyridazines
journal contribution
posted on 2015-03-20, 00:00 authored by Xingren Zhong, Jian Lv, Sanzhong LuoA catalyst-free
[4 + 2] annulation process between in situ generated
1,2-diaza-1,3-butadienes and simple olefins has been developed.
Under mild conditions, the reactions afforded 1,4,5,6-tetrahydropyridazines,
which feature a wide range of bioactive compounds, with high yields
(up to 99% yield).