(2S,3R)-2-Aminododecan-3-ol, a New Antifungal Agent from the Ascidian
Clavelina oblonga

Kossuga, Miriam H.; MacMillan, John B.; Rogers, Evan W.; Molinski, Tadeusz F.; Nascimento, Gislene G. F.; Rocha, Rosana M.; G. S. Berlinck, Roberto

doi:10.1021/np049782q.s001

(2S,3R)-2-Aminododecan-3-ol, a New Antifungal Agent from the Ascidian Clavelina oblonga

journal contribution

posted on 2004-11-29, 00:00 authored by Miriam H. Kossuga, John B. MacMillan, Evan W. Rogers, Tadeusz F. Molinski, Gislene G. F. Nascimento, Rosana M. Rocha, Roberto G. S. Berlinck

A new antifungal agent, (2S,3R)-2-aminododecan-3-ol (1), has been isolated from the ascidian Clavelina oblonga collected in Brazil. The structure of 1 was established by analysis of spectroscopic data, including absolute stereochemistry determined by circular dichroism analysis of the dibenzoyl derivative 2. Compound 1 displayed antifungal activity against Candida albicans ATCC 10231 with a MIC of 0.7 μg/mL and against Candida glabrata with a MIC of 30 μg/mL.

(2S,3R)-2-Aminododecan-3-ol, a New Antifungal Agent from the Ascidian Clavelina oblonga

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