(+)-Rimocidin Synthetic Studies. Construction of an Advanced C(1−18) Polyol Fragment
journal contributionposted on 01.07.2003, 00:00 by Amos B. Smith, Suresh M. Pitram, Michael J. Fuertes
The synthesis of an appropriately functionalized advanced C(1−18) polyol fragment of the mycosamine-glycosylated polyene macrolide, (+)-rimocidin (1), has been achieved in a highly efficient manner. Highlights of the strategy include the SN2/SN2‘ addition of dithiane anions to vinyl epoxides and the multicomponent linchpin union of 2-TBS-1,3-dithiane with two advanced epoxides.