Zn(II)-Catalyzed Synthesis of Piperidines from Propargyl Amines and Cyclopropanes

Lebold, Terry P.; Leduc, Andrew B.; Kerr, Michael A.

doi:10.1021/ol901435k.s001

Zn(II)-Catalyzed Synthesis of Piperidines from Propargyl Amines and Cyclopropanes

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posted on 2009-08-20, 00:00 authored by Terry P. Lebold, Andrew B. Leduc, Michael A. Kerr

The reaction of benzyl-protected propargyl amines and 1,1-cyclopropane diesters in the presence of catalytic Zn(NTf₂)₂ allows access to highly functionalized piperidines in excellent yields. The process proceeds via a tandem cyclopropane ring-opening/Conia−ene cyclization.

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Piperidine presence cyclization access Propargyl Amines Cyclopropane propargyl Synthesi amines diester functionalized piperidines cyclopropane Zn yield tandem process proceeds

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CC BY-NC 4.0

Zn(II)-Catalyzed Synthesis of Piperidines from Propargyl Amines and Cyclopropanes

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