Xylylene Clips for the
Topology-Guided Control of
the Inclusion and Self-Assembling Properties of Cyclodextrins

Neva, Tania; Carmona, Thais; Benito, Juan M.; Przybylski, Cédric; Mellet, Carmen Ortiz; Mendicuti, Francisco; M. García Fernández, José

doi:10.1021/acs.joc.8b00602.s001

Xylylene Clips for the Topology-Guided Control of the Inclusion and Self-Assembling Properties of Cyclodextrins

journal contribution

posted on 2018-04-23, 00:00 authored by Tania Neva, Thais Carmona, Juan M. Benito, Cédric Przybylski, Carmen Ortiz Mellet, Francisco Mendicuti, José M. García Fernández

The topology of β-cyclodextrin can be molded, from toroidal to ovoid basket-shaped, by the installation of an o- or m-xylylene moiety connecting two consecutive d-glucopyranosyl units through the secondary O-2(I) and O-3(II) positions. This strategy can be exploited advantageously to precast the cavity for preferential inclusion of globular or planar guests as well as to privilege dimeric or monomeric species in water solution.