ol0529546_si_001.pdf (209.62 kB)
Download file

Which NICS Aromaticity Index for Planar π Rings Is Best?

Download (209.62 kB)
journal contribution
posted on 02.03.2006, 00:00 by Hossein Fallah-Bagher-Shaidaei, Chaitanya S. Wannere, Clémence Corminboeuf, Ralph Puchta, Paul v. R. Schleyer
Five increasingly sophisticated aromaticity indexes, based on nucleus-independent chemical shifts (NICS), were evaluated against a uniform set of aromatic stabilization energies (ASE) for 75 mono- and polyheterocyclic five-membered rings. While acceptable statistical correlations were given by all of the NICS methods, the most fundamentally grounded index, NICS(0)πzz (based on the π contribution to the out-of-plane zz tensor component), performed best statistically (cc = 0.980) and in practice. The easily computable NICS(1)zz index is a useful alternative (cc = 0.968).