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Weak Coordination Enabled Switchable C4-Alkenylation and Alkylation of Indoles with Allyl Alcohols

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journal contribution
posted on 17.02.2020, 20:40 by Sourav Pradhan, Manmath Mishra, Pinaki Bhusan De, Sonbidya Banerjee, Tharmalingam Punniyamurthy
A weak carbonyl coordination facilitated tunable reactivity between alkenylation and alkylation of indoles at the C4 C–H site is presented using readily accessible allylic alcohols in the presence of Rh catalysis by switching the additives or directing group. Exclusive site selectivity, functional group tolerance, and late-stage modifications are the important practical features.