Water-Soluble Glutamic Acid Derivatives Produced in Culture by Penicillium solitum IS1‑A from King George Island, Maritime Antarctica
journal contribution
posted on 2020-01-02, 20:04 authored by Julie
P. G. Rodríguez, Darlon I. Bernardi, Juliana R. Gubiani, Juliana Magalhães de Oliveira, Raquel P. Morais-Urano, Ariane F. Bertonha, Karin F. Bandeira, Jairo I. Q. Bulla, Lara D. Sette, Antonio G. Ferreira, João M. Batista, Thayná
de Souza Silva, Raquel Alves dos Santos, Carlos H. G. Martins, Simone P. Lira, Marcos G. da Cunha, Daniela B. B. Trivella, Nathalia Grazzia, Natália E. S. Gomes, Fernanda Gadelha, Danilo C. Miguel, Ana Carolina G. Cauz, Marcelo Brocchi, Roberto G. S. BerlinckA new method of screening was developed
to generate 770 organic
and water-soluble fractions from extracts of nine species of marine
sponges, from the growth media of 18 species of marine-derived fungi,
and from the growth media of 13 species of endophytic fungi. The screening
results indicated that water-soluble fractions displayed significant
bioactivity in cytotoxic, antibiotic, anti-Leishmania, anti-Trypanosoma cruzi, and inhibition of proteasome
assays. Purification of water-soluble fractions from the growth medium
of Penicillium solitum IS1-A provided the new glutamic
acid derivatives solitumine A (1), solitumine B (2), and solitumidines A–D (3–6). The structures of compounds 1–6 have been established by analysis of spectroscopic data,
chemical derivatizations, and vibrational circular dichroism calculations.
Although no biological activity could be observed for compounds 1–6, the new structures reported for 1–6 indicate that the investigation of
water-soluble natural products represents a relevant strategy in finding
new secondary metabolites.
