ol015816z_si_001.pdf (426.15 kB)
Water-Accelerated Tandem Claisen Rearrangement−Catalytic Asymmetric Carboalumination
journal contribution
posted on 2001-04-14, 00:00 authored by Peter Wipf, Seth RibeThe addition of stoichiometric quantities of water accelerates both the trimethylaluminum-mediated aromatic Claisen reaction and the chiral
zirconocene-catalyzed asymmetric carboalumination of terminal alkenes. The two reactions occur in a tandem sequence resulting in the
selective formation of two new C−C and one C−O bond after oxidative quench of the intermediate trialkylalane.