Water-Accelerated Nickel-Catalyzed α‑Crotylation of Simple Ketones with 1,3-Butadiene under pH and Redox-Neutral Conditions
journal contributionposted on 19.03.2020, 20:30 by Tiantian Chen, Haijian Yang, Yang Yang, Guangbin Dong, Dong Xing
We report a nickel/NHC-catalyzed branched-selective α-crotylation of simple ketones using 1,3-butadiene as the alkylation agent. This reaction is regioselective and operated under pH and redox-neutral conditions. Water was used as the sole additive, which significantly accelerates the transformation.