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Voltage-Dependent Properties of DNA Origami Nanopores

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journal contribution
posted on 12.03.2014, 00:00 by Silvia Hernández-Ainsa, Karolis Misiunas, Vivek V. Thacker, Elisa A. Hemmig, Ulrich F. Keyser
We show DNA origami nanopores that respond to high voltages by a change in conformation on glass nanocapillaries. Our DNA origami nanopores are voltage sensitive as two distinct states are found as a function of the applied voltage. We suggest that the origin of these states is a mechanical distortion of the DNA origami. A simple model predicts the voltage dependence of the structural change. We show that our responsive DNA origami nanopores can be used to lower the frequency of DNA translocation by 1 order of magnitude.