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Vitamin B12 Derivatives as Activators of Soluble Guanylyl Cyclase

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journal contribution
posted on 25.10.2012, 00:00 by Keith ó Proinsias, Daniel T. Gryko, Yoshio Hisaeda, Emil Martin, Jonathan L. Sessler, Dorota Gryko
Various newly prepared and previously known vitamin B12 derivatives have been studied as potential soluble guanylyl cyclase (sGC) activators. All compounds tested were found to activate the sGC enzyme, although to differing extents. The best results were obtained with the derivatives synthesized from c-lactone and possessing aliphatic amides in the c- and d-positions.