posted on 2012-10-25, 00:00authored byKeith ó Proinsias, Daniel T. Gryko, Yoshio Hisaeda, Emil Martin, Jonathan L. Sessler, Dorota Gryko
Various newly prepared and previously known vitamin B12 derivatives have been studied as potential soluble guanylyl
cyclase
(sGC) activators. All compounds tested were found to activate the
sGC enzyme, although to differing extents. The best results were obtained
with the derivatives synthesized from c-lactone and
possessing aliphatic amides in the c- and d-positions.