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Visibly Emitting Thiazolyl-Uridine Analogues as Promising Fluorescent Probes

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journal contribution
posted on 19.03.2020, 17:03 authored by Jinsi Li, Xuerong Fang, Xin Ming
Microenvironment-sensitive fluorescent (ESF) nucleosides are powerful tools for nucleic acid research. The new 5-substituted uridine analogues are synthesized, which comprise a 4H-cyclopenta­[d]­thiazole ring obtained by the Hantzsch synthesis reaction of 5-thioamide-uridine with aromatic α-bromocarbonyl compounds. The emission maximum of new compounds is in the visible region. They exhibit strong solvent- and pH-dependent fluorescent properties, indicating their promising ability to be fluorescent probes.