ol7b03896_si_001.pdf (9.13 MB)
Visible-Light Photoredox/Nickel Dual Catalysis for the Cross-Coupling of Sulfinic Acid Salts with Aryl Iodides
journal contribution
posted on 2018-01-16, 03:13 authored by Nai-Wei Liu, Kamil Hofman, André Herbert, Georg ManolikakesAn efficient cross-coupling
of sodium or lithium sulfinates with
aryl iodides, using a combination of nickel and photoredox catalysis,
is described. The dual catalyst system enables a versatile synthesis
of aryl sulfones at room temperature in good yields and displays a
broad functional group compatibility. The potential utility of this
method in the late-stage diversification of complex molecules and
in the conversion of organolithium reagents and sulfur dioxide into
sulfones is demonstrated.
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aryl sulfonesPhotoredoxlithium sulfinatescross-couplingaryl iodidesutilitysodiumCatalysiSulfinicmethodsynthesislate-stage diversificationcombinationmoleculeconversionCross-CouplingAryl Iodidescatalyst systemgroup compatibilitysulfur dioxideyieldorganolithium reagentsVisible-Lightroom temperaturephotoredox catalysisdisplay