Visible-Light-Promoted Radical Cross-Dehydrogenative Coupling of C(sp³)–H/C(sp³)–H and C(sp³)–H/C(sp²)–H via Intermolecular HAT

Cross-dehydrogenative coupling has emerged as a robust tool to construct C–C and C–heteroatom bonds. Herein, we reported an interesting visible-light-mediated radical CDC of C(sp³)–H/C(sp³)–H and C(sp³)–H/C(sp²)–H, enabled by a phenyl radical guided intermolecular HAT process. This strategy allowed the efficient coupling of a wide range of inert C(sp³)–H and C(sp²)–H with α-N C(sp³)–H of amines in good regioselectivities and yields. Mechanistic studies indicate that the EDA complex triggered an intermolecular HAT process.