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Visible-Light-Mediated Remote γ‑C(sp3)–H Functionalization of Alkylimidates: Synthesis of 4‑Iodo-3,4-dihydropyrrole Derivatives

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journal contribution
posted on 2018-08-07, 18:35 authored by Yogesh Kumar, Yogesh Jaiswal, Amit Kumar
An efficient and environmentally friendly synthetic approach toward functionalized dihydropyrrole derivatives is reported. The developed protocol proceeds via chemoselective intramolecular N–C bond formation of alkylimidates through 1,5-hydrogen atom transfer from in situ generated imidate N-radicals. The major advantage of this designed strategy lies in the choice of starting materials, mild reaction conditions, high chemo- and diastereoselectivity, clean source of energy, and good functional group tolerance. Further, 4-iododihydropyrroles could be easily transformed into a variety of useful derivatives.

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