Visible-Light-Mediated Nickel(II)-Catalyzed C–N
Cross-Coupling in Water: Green and Regioselective Access for the Synthesis
of Pyrazole-Containing Compounds
posted on 2018-06-26, 13:22authored byGuirong You, Kai Wang, Xiaodan Wang, Guodong Wang, Jian Sun, Guiyun Duan, Chengcai Xia
A regioselective
green approach for the nickel(II)-catalyzed C–N
cross-coupling between arylamines and pyrazoles through a photoredox
process is reported. Moderate to good yield was observed for this
reaction, performed in water under air at room temperature. This strategy
provides a powerful tool for the green synthesis of pyrazole-containing
bioactive molecules. In addition, a single-electron-transfer mechanism
is proposed in this report.