Visible-Light-Mediated Deaminative Three-Component Dicarbofunctionalization of Styrenes with Benzylic Radicals
journal contributionposted on 2018-11-26, 00:00 authored by Felix J. R. Klauck, Hyung Yoon, Michael J. James, Mark Lautens, Frank Glorius
The visible-light-mediated three-component dicarbofunctionalization of styrenes using simple benzylic radicals is described. Notably, this work describes a rare example of undirected dicarbofunctionalization using unsubstituted benzyl radicals. Key to the success of this strategy was the rational design and use of benzylic pyridinium salts as radical precursors. Using this approach, abundant styrenes, electron-rich heterocycles, and benzylic amines were combined to rapidly afford a number of densely functionalized 1,1-diarylalkanes. A dipeptide-derived pyridinium salt was applied in this transformation, which resembles a visible-light-mediated deaminative generation of radicals from peptides.
visible-light-mediated three-component dicarbofunctionalizationvisible-light-mediated deaminative generationbenzylic aminesdipeptide-derived pyridinium saltstyreneunsubstituted benzyl radicalselectron-rich heterocyclesundirected dicarbofunctionalizationVisible-Light-Mediated Deaminative Three-Component Dicarbofunctionalizationbenzylic radicalsbenzylic pyridinium saltsBenzylic Radicals