Visible-Light-Induced Tertiary C(sp3)–H Sulfonylation: An Approach to Tertiary Sulfones
journal contributionposted on 01.02.2021, 12:34 by Sumedha Swarnkar, Mohd Yeshab Ansari, Atul Kumar
In seeking to broaden the lexicon of photocatalysis and considering the importance of sulfones as essential pharmaceuticals, herein one-pot visible-light-induced tertiary C(sp3)–H sulfonylation is explored for the first time using indoline-2,3-diones, 4-hydroxy proline, and sulfinic acids as model substrates in the presence of iodine and Na2-Eosin Y as a photocatalyst. In addition, this transformation unlocks a new strategy in the context of the late-stage tertiary C(sp3)–H sulfonylation of Monastrol, a selective Eg5 inhibitor, and its analogue.
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iodineVisible-Light-InducedlexiconanalogueApproachindolinephotocatalysione-pot visible-light-inducedpresencestrategyEosin Ysulfone4-MonastrolNa 2prolinetransformationSulfonylationcontextpharmaceuticalimportancemodel substratessulfonylationEg 5 inhibitorphotocatalystTertiary Sulfonessulfinic acidshydroxylate-stage