American Chemical Society
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Visible-Light-Induced Radical gem-Iodoallylation of 2,2,2-Trifluorodiazoethane

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journal contribution
posted on 2023-03-13, 15:05 authored by Yu Liu, Tengfei Pang, Weijun Yao, Fangrui Zhong, Guojiao Wu
A visible-light-induced radical gem-iodoallylation of CF3CHN2 was developed under mild conditions, delivering a variety of α-CF3-substituted homoallylic iodide compounds in moderate to excellent yields. The transformation features broad substrate scope, good functional group compatibility, and operational simplicity. The described protocol provides a convenient and attractive tool to apply CF3CHN2 as CF3-introduction reagent in radical synthetic chemistry.

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