posted on 2022-01-18, 15:38authored byZhi-Lin Liu, Zhi-Peng Ye, Yi-Xuan Chen, Yu Zheng, Zhen-Zhen Xie, Jian-Ping Guan, Jun-An Xiao, Kai Chen, Hao-Yue Xiang, Hua Yang
A highly modular 1,4-difunctionalization
of 1,3-dienes with bromodifluoroacetamides
and sulfinates/amines through a photoinduced palladium-catalyzed radical
relay process is described herein. This developed protocol offers
a facile and general route to access a variety of value-added CF2-incorporated alkenes in moderate to good yields. The versatility
and flexibility of this approach have been well illustrated by readily
accessible starting materials, synthetic convenience, and wide functional
group compatibility.