American Chemical Society
jo3c02183_si_001.pdf (7.46 MB)

Visible-Light-Induced Cascade Cyclization of 1‑Acryloyl-2-cyanoindole: Access of Difluoroalkylated Pyrrolo[1,2‑a]indolediones

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journal contribution
posted on 2023-11-10, 18:40 authored by Jinwei Yuan, Lu Shen, Na Guo, Yanli Yin, Pengyuan Yang, Liangru Yang, Yongmei Xiao, Shouren Zhang
An effective method for accessing diverse difluoroalkylated pyrrolo[1,2-a]indolediones via visible-light-induced PhI(OAc)2-promoted cascade difluoroalkylation/cyclization reaction under mild conditions has been established. This method is noteworthy for its use of DMSO–H2O as a green medium at room temperature and avoidance of photocatalysts. The reactions are straightforward to execute and convenient to expand on, provide good to excellent yields, and have good functional group tolerance.