American Chemical Society
jo5b02367_si_002.pdf (8.87 MB)

Viridicatumtoxins: Expanding on a Rare Tetracycline Antibiotic Scaffold

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journal contribution
posted on 2015-12-18, 00:00 authored by Zhuo Shang, Angela A. Salim, Zeinab Khalil, Michelle Quezada, Paul V. Bernhardt, Robert J. Capon
Viridicatumtoxins, which belong to a rare class of fungal tetracycline-like mycotoxins, were subjected to comprehensive spectroscopic and chemical analysis, leading to reassignment/assignment of absolute configurations and characterization of a remarkably acid-stable antibiotic scaffold. Structure activity relationship studies revealed exceptional growth inhibitory activity against vancomycin-resistant Enterococci (IC50 40 nM), >270-fold more potent than the commercial antibiotic oxytetracycline.