posted on 2015-12-18, 00:00authored byZhuo Shang, Angela
A. Salim, Zeinab Khalil, Michelle Quezada, Paul V. Bernhardt, Robert J. Capon
Viridicatumtoxins,
which belong to a rare class of fungal tetracycline-like
mycotoxins, were subjected to comprehensive spectroscopic and chemical
analysis, leading to reassignment/assignment of absolute configurations
and characterization of a remarkably acid-stable antibiotic scaffold.
Structure activity relationship studies revealed exceptional growth
inhibitory activity against vancomycin-resistant Enterococci (IC50 40 nM), >270-fold more potent than the commercial
antibiotic oxytetracycline.