Versatile Synthesis of Head Group Functionalized Phospholipids via Oxime Bond Formation

Furuta, Takumi; Mochizuki, Masayoshi; Ito, Mai; Takahashi, Tadanobu; Suzuki, Takashi; Kan, Toshiyuki

doi:10.1021/ol8019346.s002

ol8019346_si_002.pdf (5.15 MB)

Versatile Synthesis of Head Group Functionalized Phospholipids via Oxime Bond Formation

journal contribution

posted on 2008-11-06, 00:00 authored by Takumi Furuta, Masayoshi Mochizuki, Mai Ito, Tadanobu Takahashi, Takashi Suzuki, Toshiyuki Kan

A method for introduction of various head groups on phospholipid frameworks via oxime bond formation has been developed for the synthesis of cyclen−Cu(II), pyrene, naphthalene, and other headgroup functionalized phospholipids that can cleave the membrane protein, hemagglutinin.