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Use of a Retroinverso p53 Peptide as an Inhibitor of MDM2

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journal contribution
posted on 22.12.2004, 00:00 authored by Kaori Sakurai, Hak Suk Chung, Daniel Kahne
An N-terminal helical region of the tumor suppressor p53 binds in a hydrophobic cleft of the oncoprotein MDM2. A retroinverso isomer of the natural N-terminal helical peptide was found to interact with MDM2 using the same hydrophobic residues, Phe, Trp, and Leu. We propose that the retroinverso d-peptide adopts a right-handed helical conformation to achieve functional mimicry of the p53 peptide.