Use of a Cyclometalated
Iridium(III) Complex Containing
a N∧C∧N-Coordinating Terdentate
Ligand as a Catalyst for the α‑Alkylation of Ketones
and N‑Alkylation of Amines with Alcohols
posted on 2017-01-05, 00:00authored byPengcheng Liu, Ran Liang, Lei Lu, Zhentao Yu, Feng Li
A cyclometalated iridium(III) complex
containing a N∧C∧N-coordinating
terdentate ligand [Ir(dpyx-N,C,N)Cl(μ-Cl)]2 was found to be a general
and highly effective catalyst for
the α-alkylation of ketones and N-alkylation
of amines with alcohols. In the presence of catalyst (1 mol % Ir)
and base (0.2–0.5 equiv), a variety of desirable products were
obtained in good yields under an air atmosphere. Notably, this research
exhibited the new potential of Ir(III) complexes bearing non-Cp* ligand
and will facilitate the progress of the hydrogen autotransfer process.