American Chemical Society
ol049716f_si_002.pdf (71.64 kB)

Use of InCl3 as a Cocatalyst and a Cl2Pd(DPEphos)−P(2-Furyl)3 Catalyst System for One-Pot Hydrometalation−Cross-Coupling and Carbometalation−Cross-Coupling Tandem Processes

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journal contribution
posted on 2004-05-13, 00:00 authored by Mingxing Qian, Zhihong Huang, Ei-ichi Negishi
One-pot conversion of alkynes to regio- and stereodefined alkenylmetals containing Al and Zr via hydrometalation or carbometalation followed by their Pd-catalyzed cross-coupling with (E)-ICHCHBr or (E)-ICHCHCl proceeds cleanly and selectively to give the corresponding 1-halo-1,3-dienes in excellent yields using a catalyst system consisting of Cl2Pd(DPEphos), DIBAL-H, and TFP (catalyst A) with InCl3 as a cocatalyst.