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Unusual Sulfamate Indoles and a Novel Indolo[3,2-a]carbazole from Ancorina sp.

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journal contribution
posted on 24.08.2002, 00:00 by Karina M. Meragelman, Lyndon M. West, Peter T. Northcote, Lewis K. Pannell, Tawnya C. McKee, Michael R. Boyd
Four new indoles, ancorinolates A−C and bis-ancorinolate B, which contain sulfamate and sulfate groups, were isolated from the aqueous extract of the sponge Ancorina sp. In addition, ancorinazole, an indolo[3,2-a]carbazole also possessing sulfamate and sulfate groups, was isolated from two separate New Zealand collections of Ancorina sp. Ancorinazole is the first indolo[3,2-a]carbazole described as a natural product. Ancorinolates A (1) and C (3) showed weak HIV-inhibitory activity in the XTT-based, anticytopathicity assay.