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Unusual Dimeric Chemical Structure for a Carboplatin Analogue as a Potential Anticancer Complex

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journal contribution
posted on 05.07.2010, 00:00 authored by Mingjin Xie, Weiping Liu, Liguang Lou, Xizhu Chen, Qingsong Ye, Yao Yu, Qiaowen Chang, Shuqian Hou
An unexpected and unusual dimeric platinum(II) tetracarboxylate complex was obtained by the reaction of cis-[Pt(NH3)2I2] with disilver dicarboxylate. The complex exhibits greater in vitro anticancer activity and lower toxicity in mice than its parent compound, carboplatin, and is therefore worthy of further evaluation as a potential antitumor dinuclear platinum agent.