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Unravelling the Conformational Plasticity of the Extracellular Domain of a Prokaryotic nAChR Homologue in Solution by NMR

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posted on 22.02.2016, 15:25 by Christos T. Chasapis, Aikaterini I. Argyriou, Pierre-Jean Corringer, Detlef Bentrop, Georgios A. Spyroulias
Pentameric ligand-gated ion channels (pLGICs) of the Cys loop family are transmembrane glycoproteins implicated in a variety of biological functions. Here, we present a solution NMR study of the extracellular domain of a prokaryotic pLGIC homologue from the bacterium Gloeobacter violaceus that is found to be a monomer in solution.