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Unified, Radical-Based Approach for the Synthesis of Spiroketals

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journal contribution
posted on 02.04.2020, 17:22 by Michiel de Greef, Samir Z. Zard
Functionalization of S-(3-chloro-2-oxo-propyl)-O-ethyl xanthate 1 by two consecutive xanthate transfer reactions, followed by spirocyclization of the resulting dihydroxy ketones, provides a flexible and highly convergent access to diversely substituted spiroketals, containing five-, six-, and seven-membered rings.