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Unexpected Formation of Tetrasubstituted 2,3-Dihydrofurans from the Reactions of β-Keto Polyfluoroalkanesulfones with Aldehydes

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journal contribution
posted on 17.09.2004, 00:00 by Chunhui Xing, Shizheng Zhu
Catalyzed by piperidine, the reactions of β-keto polyfluoroalkanesulfones with aromatic aldehydes afforded the unexpected tetrasubstituted 2,3-dihydrofurans in good yields, probably proceeding through the normal Knoevenagel condensation products. This reaction provided an efficient and novel method for the stereoselective synthesis of fluorine-containing tetrasubstituted trans-2,3-dihydrofurans.