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Ultrasensitive Flow Sensing of a Single Cell Using Graphene-Based Optical Sensors

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journal contribution
posted on 11.06.2014, 00:00 authored by Fei Xing, Gui-Xian Meng, Qian Zhang, Lei-Ting Pan, Peng Wang, Zhi-Bo Liu, Wen-Shuai Jiang, Yongsheng Chen, Jian-Guo Tian
On the basis of the polarization-dependent absorption of graphene under total internal reflection, we designed a graphene-based optical refractive index sensor with high resolution of 1.7 × 10–8 and sensitivity of 4.3 × 107 mV/RIU, as well as an extensive dynamic range. This highly sensitive graphene optical sensor enables label-free, live-cell, and highly accurate detection of a small quantity of cancer cells among normal cells at the single-cell level and the simultaneous detection and distinction of two cell lines without separation. It provides an accurate statistical distribution of normal and cancer cells with fewer cells. This facile and highly sensitive sensing refractive index may expand the practical applications of the biosensor.