posted on 2016-02-20, 03:13authored byAndreas
T. Messmer, Sabrina Steinwand, Katharina M. Lippert, Peter R. Schreiner, Jens Bredenbeck
Structure determination of reactive species is a key
step in understanding
reaction mechanisms. We demonstrate the application of polarization-dependent
two-dimensional infrared spectroscopy (P2D-IR) as a powerful tool
combining structure resolution with ultrafast time resolution. We
apply this technique to investigate the substrate–catalyst
complexes in a Lewis acid catalyzed Diels–Alder reaction. Using
Mg(ClO4)2 as a Lewis acid, we found that an
additional complex besides the chelate typically postulated as reactive
species forms. Experimental access to this new species leads to a
deeper understanding of the observed selectivities for the Diels–Alder
reaction catalyzed by Lewis acids. Our findings are supported by density
functional computations at the M06/6-31+G(d,p) level, including solvent corrections.