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Tyrosinase-Inhibitory Constituents from the Twigs of Cinnamomum cassia

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journal contribution
posted on 26.06.2009, 00:00 by Tran Minh Ngoc, IkSoo Lee, Do Thi Ha, HongJin Kim, ByungSun Min, KiHwan Bae
A methanol extract of the twigs of Cinnamomum cassia was found to possess inhibitory activity against tyrosinase. Purification of the MeOH extract afforded four new phenolics, cassiferaldehyde (6), icariside DC (9), cinnacassinol (10), and dihydrocinnacasside (13), together with 10 known compounds (15, 712, and 14). The structures of the new compounds were determined by spectroscopic data interpretation. Compounds 16 and 813 showed strong inhibitory activity against tyrosinase, with IC50 values ranging from 0.24 to 0.94 mM.