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Two Novel Glycosidic Triterpene Alkaloids from the Stem Barks of Machilus yaoshansis

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journal contribution
posted on 04.01.2007, 00:00 by Ming-Tao Liu, Sheng Lin, Ying-Hong Wang, Wen-Yi He, Shuai Li, Su-Juan Wang, Yong-Chun Yang, Jian-Gong Shi
Two unusual glycosidic triterpene alkaloids, machilaminosides A (1) and B (2), have been isolated from the stem barks of Machilus yaoshansis. Their structures were elucidated by detailed spectroscopic analysis. A possible biogenetic origin of 1 and 2 mediated by the coupling of 2-O-β-d-glucopyranosyl-cucurbitacin I, respectively, with urea and adenosine was postulated. 1 and 2 showed nonselective cytotoxic activities against several human cancer cell lines as well as TNF-α secretion inhibitory activities.