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Two Furanharzianones with 4/7/5/6/5 Ring System from Microbial Transformation of Harzianone

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journal contribution
posted on 20.02.2017, 20:49 by Min Zhang, Jimei Liu, Ridao Chen, Jinlian Zhao, Kebo Xie, Dawei Chen, Keping Feng, Jungui Dai
Furanharzianones A and B (2 and 3), two new harziane-type diterpenoids with a tetrahydrofuran and unusual 4/7/5/6/5 ring system, were obtained from the microbial transformation of harzianone (1) by a bacterial strain Bacillus sp. IMM-006. The structures, including the stereochemistry, of the two new compounds were elucidated by extensive spectroscopic analysis. The absolute configuration of 2 was unambiguously determined by single-crystal X-ray diffraction. In addition, a plausible bioconversion pathway was proposed.

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