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Tuning the Organelle-Specific Imaging and Photodynamic Therapeutic Efficacy of Theranostic Mono- and Trinuclear Organometallic Iridium(III) Complexes
journal contributionposted on 2023-11-13, 17:05 authored by Bishnu Das, Subhadeep Gupta, Anushka Mondal, Kalyan Jyoti Kalita, Amirul Islam Mallick, Parna Gupta
The organelle-specific localization of mononuclear and trinuclear iridium(III) complexes and their photodynamic behavior within the cells are described herein, emphasizing their structure–activity relationship. Both the IrA2 and IrB2 complexes possess a pair of phenyl-benzothiazole derived from the −CHO moieties of mononuclear organometallic iridium(III) complexes IrA1 and IrB1, which chelates IrCp*Cl (Cp* = 1,2,3,4,5-pentamethylcyclopentadiene) to afford trinuclear complexes IrA3 and IrB3. Insights into the photophysical and electrochemical parameters of the complexes were obtained by a time-dependent density functional theory study. The synthesized complexes IrA2, IrA3, IrB2, and IrB3 were found to be nontoxic to human MCF7 breast carcinoma cells. However, the photoexcitation of complexes using LED light could effectively trigger intracellular reactive oxygen species (ROS) generation, leading to cell death. Furthermore, to check the organelle-specific localization of IrA2 and IrB2, we observed that both complexes could selectively localize in the endoplasmic reticulum. In contrast, trinuclear IrA3 and IrB3 accumulate in the nuclei. The photoexcitation of complexes using LED light could effectively trigger intracellular reactive oxygen species (ROS) generation, leading to cell death.
− cho moietiesphotodynamic therapeutic efficacyphotodynamic behavior withintrinuclear organometallic iridiummononuclear organometallic iridiumsynthesized complexes ira2irb2 complexes possesstrinuclear iridiumcomplexes ira1theranostic monospecific localizationspecific imagingendoplasmic reticulumelectrochemical parametersdescribed hereinchelates ircpcell deathbenzothiazole derived