nn1c07275_si_001.pdf (5.39 MB)
Tumor Microenvironment Responsive “Head-to-Foot” Self-Assembly Nanoplatform for Positron Emission Tomography Imaging in Living Subjects
journal contribution
posted on 2021-11-05, 11:34 authored by Ling Qiu, Ke Li, Wenyi Dong, Yann Seimbille, Qingzhu Liu, Feng Gao, Jianguo LinSensitivity
and specificity of molecular probes are two important
factors in determining the accuracy of cancer diagnosis or the efficacy
of cancer treatment. However, the development of probes with high
sensitivity and strong specificity still poses many challenges. Herein,
we report an 18F-labeled smart tracer ([18F]1) targeting cancer-associated biotin receptor (BR) and self-assembling
into nanoparticles in response to intracellular glutathione. The tracer
[18F]1 selectively targeted BR-positive cancer
cells A549 and Hela and formed nanoparticles through self-assembly
with an average diameter of 138.2 ± 16.3 nm. The character of
self-assembly into nanoparticles enhanced the uptake and extended
the retention of probe [18F]1 in the target
tissue and hence improved the quality of positron emission tomography
(PET) images. Thus, [18F]1 is a promising
PET tracer for accurately detecting BR-positive cancers. Moreover,
the tumor microenvironment responsive “head-to-foot”
self-assembly nanoplatform is particularly attractive for development
of other smart molecular probes.
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two important factorspositron emission tomographyassociated biotin receptor2 ± 161 bliving subjects sensitivity18 supselectively targeted braccurately detecting brtracer [< supprobe [< suppromising pet tracerfoot ” selff ]< bsmart molecular probes[< supmolecular probeshigh sensitivitytarget tissuepositive cancersparticularly attractiveintracellular glutathionehence improvedcancer treatmentcancer diagnosisaverage diameter3 nm