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Triplex Formation with α-L-LNA (α-l-Ribo-Configured Locked Nucleic Acid)

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journal contribution
posted on 11.01.2006, 00:00 by Niti Kumar, Katrine E. Nielsen, Souvik Maiti, Michael Petersen
Using UV melting and CD spectroscopy, we show that α-l-LNA-modified oligonucleotides possess the ability to form triplexes at pH 6.8 with significantly increased thermostability relative to DNA triplexes.