ol7b02139_si_001.pdf (2.56 MB)
Trifluoromethylthiolation-Based Bifunctionalization of Diazocarbonyl Compounds by Rhodium Catalysis
journal contribution
posted on 2017-08-16, 21:09 authored by Marvin Lübcke, Weiming Yuan, Kálmán J. SzabóA new Rh-catalyzed,
three-component reaction for the oxytrifluoromethylthiolation
of α-diazoketones was developed. The SCF3 functionality
was introduced using a stable dibenzenesulfonimide reagent under mild
conditions. Alcohols, acetals, and ethers were used as the alkoxy
sources. Cyclic ethers underwent a trifunctionalization reaction through
the introduction of SCF3, OR, and N(SO2Ph)2 substituents in a single step.
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α- diazoketones2 substituentsSCF 3 functionalityPhDiazocarbonyl Compoundstrifunctionalization reactionRhodium CatalysisacetalSCF 3oxytrifluoromethylthiolationthree-component reactionTrifluoromethylthiolation-Based BifunctionalizationCyclic ethersdibenzenesulfonimide reagentRh-catalyzedalkoxy sourcesintroduction
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