Trifluoromethylation of Alkenyl Bromides and
Iodides (Including 5-Iodouracils) with (CF3)2Hgand Cu (“Trifluoromethylcopper”)1

Nowak, Ireneusz; Robins, Morris J.

doi:10.1021/jo062544a.s001

jo062544a_si_001.pdf (7.3 MB)

Trifluoromethylation of Alkenyl Bromides and Iodides (Including 5-Iodouracils) with (CF₃)₂Hgand Cu (“Trifluoromethylcopper”)¹

journal contribution

posted on 2007-03-30, 00:00 authored by Ireneusz Nowak, Morris J. Robins

Bromo- and iodoalkenes undergo trifluoromethylation efficiently in DMA with “CF₃Cu” generated from (CF₃)₂Hg and Cu. Variable stereochemical inversion is observed with substrates having a gem-carbonyl group. Substrates having gem-hydrogen, -alkyl, or -alkenyl groups give products with stereochemical retention.