American Chemical Society
jo062544a_si_001.pdf (7.3 MB)

Trifluoromethylation of Alkenyl Bromides and Iodides (Including 5-Iodouracils) with (CF3)2Hgand Cu (“Trifluoromethylcopper”)1

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journal contribution
posted on 2007-03-30, 00:00 authored by Ireneusz Nowak, Morris J. Robins
Bromo- and iodoalkenes undergo trifluoromethylation efficiently in DMA with “CF3Cu” generated from (CF3)2Hg and Cu. Variable stereochemical inversion is observed with substrates having a gem-carbonyl group. Substrates having gem-hydrogen, -alkyl, or -alkenyl groups give products with stereochemical retention.