Trifluoromethyl Vinyl
Sulfide: A Building Block for
the Synthesis of CF3S‑Containing Isoxazolidines

Riesco-Domínguez, Alejandra; van de Wiel, Jeroen; Hamlin, Trevor A.; van Beek, Bas; Lindell, Stephen D.; Blanco-Ania, Daniel; Bickelhaupt, F. Matthias; P. J. T. Rutjes, Floris

doi:10.1021/acs.joc.7b02639.s002

- No file added yet -

Trifluoromethyl Vinyl Sulfide: A Building Block for the Synthesis of CF₃S‑Containing Isoxazolidines

journal contribution

posted on 2018-01-10, 00:00 authored by Alejandra Riesco-Domínguez, Jeroen van de Wiel, Trevor A. Hamlin, Bas van Beek, Stephen D. Lindell, Daniel Blanco-Ania, F. Matthias Bickelhaupt, Floris P. J. T. Rutjes

Trifluoromethyl vinyl sulfide, a potential building block for pharmaceutically and agrochemically relevant products, is prepared and used for the first time in high-pressure-mediated 1,3-dipolar cycloaddition reactions with nitrones to synthesize (trifluoromethyl)sulfanyl isoxazolidines.