jo9b03112_si_001.pdf (4.22 MB)
Download fileTriflic Acid-Catalyzed Cycloisomerization of 1,6-Enynes: Facile Access to Carbo- and Azaheterocycles
journal contribution
posted on 2020-01-06, 23:29 authored by Xiang Liu, Yuhan Wang, Jinlei Zhou, Yue Yu, Hua CaoA new and efficient strategy for
enynes cyclization catalyzed by
triflic acid has been described. Various valuable carbocycle-fused
and heterocycle-fused ketones were easily accessed by the formation
of new C–C and C–O bond under benign reaction conditions.
This protocol also provides another opportunity to construct polycyclic
single-nitrogen ketones via a cation-induced cascade cyclization of
polyenynes. Furthermore, antiviral bioassays revealed that a few compounds
exhibited good antiviral activity against tobacco mosaic virus at
a concentration of 200 μg mL–1.
History
Usage metrics
Read the peer-reviewed publication
Categories
Keywords
Enynereaction conditionsAzaheterocycleVariouscation-induced cascade cyclizationtobacco mosaic virusconcentrationmLenynes cyclizationstrategybioassaytriflic acidheterocycle-fused ketonescarbocycle-fusedformationcompoundTriflic Acid-Catalyzed CycloisomerizationopportunityCarbopolycyclic single-nitrogen ketonespolyenynebondFacile Access