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Triflic Acid-Catalyzed Cycloisomerization of 1,6-Enynes: Facile Access to Carbo- and Azaheterocycles

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journal contribution
posted on 2020-01-06, 23:29 authored by Xiang Liu, Yuhan Wang, Jinlei Zhou, Yue Yu, Hua Cao
A new and efficient strategy for enynes cyclization catalyzed by triflic acid has been described. Various valuable carbocycle-fused and heterocycle-fused ketones were easily accessed by the formation of new C–C and C–O bond under benign reaction conditions. This protocol also provides another opportunity to construct polycyclic single-nitrogen ketones via a cation-induced cascade cyclization of polyenynes. Furthermore, antiviral bioassays revealed that a few compounds exhibited good antiviral activity against tobacco mosaic virus at a concentration of 200 μg mL–1.