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Trichoharzianol, a New Antifungal from Trichoderma harzianum F031

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journal contribution
posted on 15.04.2015, 00:00 by Chotika Jeerapong, Worrapong Phupong, Phuwadol Bangrak, Warin Intana, Patoomratana Tuchinda
A new decalin derivative, trichoharzianol (1), together with three known compounds, eujavanicol A (2), 5-hydroxy-3-hydroxymethyl-2-methyl-7-methoxychromone (3), and 4,6-dihydroxy-5-methylphthalide (4), were isolated from Trichoderma harzianum F031. For the first time, compounds 24 were reported from the Trichoderma species. Their structures were characterized by spectroscopic methods. Trichoharzianol (1) showed the highest antifungal activity against Colletotrichum gloeosporioides, with a minimum inhibitory concentration (MIC) of 128 μg/mL.